Article

Theoretical basis for stabilizing messenger RNA through secondary structure design

2020-08-24

Abstract excerpt

RNA hydrolysis presents problems in manufacturing, long-term storage, world-wide delivery, and in vivo stability of messenger RNA (mRNA)-based vaccines and therapeutics. A largely unexplored strategy to reduce mRNA hydrolysis is to redesign RNAs to form double-stranded regions, which are protected from in-line cleavage and enzymatic degradation, while coding for the same proteins. The amount of stabilization that...

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Literature Corpus work: beed0ba1-9eac-5985-9110-9a99d4172953
DOI: 10.1101/2020.08.22.262931

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