Article

Conserved Pseudouridines in Helix 69 of the Ribosome are Important for Ribosome Dynamics in Translation

2024-02-03

Abstract excerpt

<h4>ABSTRACT</h4> The widespread distribution of pseudouridine (Ψ), an isomer of the canonical uridine base, in RNA indicates its functional importance to the cell. In eukaryotes, it is estimated that around 2% of ribosomal RNA nucleotides are pseudouridines, most of which are located in functional regions of the ribosome. Defects in RNA pseudouridylation induce a range of detrimental effects from compromised cel...

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Literature Corpus work: f19a78b8-1c3b-5513-8ff4-27e6e2ad2f31
DOI: 10.1101/2024.02.02.578723

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