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Article

40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.

RNA (New York, N.Y.) - 16 Sept 2025

Wakabayashi Hironao, Zhu Mingyi, Grayhack Elizabeth J, Mathews David H, Ermolenko Dmitri N

Abstract excerpt

During eukaryotic translation initiation, the small (40S) ribosomal subunit is recruited to the 5' cap and subsequently scans the 5' untranslated region (5' UTR) of mRNA in search of the start codon. The molecular mechanism of mRNA scanning remains unclear, particularly the requirement for and identity of a translocase. Here, using GFP reporters in Saccharomyces cerevisiae, we show that order-of-magnitude...

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Identifiers

PMID: 40744711
DOI: 10.1261/rna.080493.125
PMCID: PMC12415969

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