Article
Structured mRNAs regulate translation initiation by binding to the platform of the ribosome.
Cell - 21 Sept 2007
Marzi Stefano, Myasnikov Alexander G, Serganov Alexander, Ehresmann Chantal, Romby Pascale, Yusupov Marat, Klaholz Bruno P
Abstract excerpt
Gene expression can be regulated at the level of initiation of protein biosynthesis via structural elements present at the 5' untranslated region of mRNAs. These folded mRNA segments may bind to the ribosome, thus blocking translation until the mRNA unfolds. Here, we report a series of cryo-electron microscopy snapshots of ribosomal complexes directly visualizing either the mRNA structure blocked by repressor...
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