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Article

RNA Folding Energy of Long-Range Genomic Interactions Regulates Discontinuous Transcription in SARS-CoV-2.

Viruses - 29 May 2026

Ross Stephen J, Ye Chengjin, Moxon Simon, Mühlberger Elke, Martinez-Sobrido Luis, Cifuentes Daniel

Abstract excerpt

Coronaviruses use discontinuous transcription to generate subgenomic RNAs (sgRNAs) that encode structural and accessory proteins. However, the factors regulating sgRNA abundance in SARS-CoV-2 remain unclear. Here, we combined strand-specific RNA sequencing, RNA-RNA interaction mapping, prediction of RNA folding energies, and targeted mutagenesis to define the regulation of (-) sgRNA synthesis in SARS-CoV-2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42357630
DOI: 10.3390/v18060620
PMCID: PMC13307601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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