Feedback from the Nascent Chain Triggers Ribosomal Frameshifting and Transcript Decay

Abstract excerpt

<h4>Summary</h4> Though ribosomes have several features that help them maintain their reading frame, these safeguards can be bypassed by RNA structures that promote −1 programmed ribosomal frameshifting (-1PRF). We recently found that conformational transitions in the nascent polypeptide can enhance -1PRF, though it’s unclear whether this feedback plays a general role in translational recoding. Here we demonstrat...

Topics

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• Frameshifting, Ribosomal
• Nucleic Acid Conformation
• Peptidase Inhibition and Analysis
• Protein Biosynthesis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• RNA, Transfer
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

dafbe479-56e4-5cc7-b134-a90e46053d4e

DOI

10.64898/2025.12.23.696290