Article

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

2020-02-06

Abstract excerpt

Although the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate programmed ribosome frameshifting via mechanisms that are not well understood. Using biochemical and single-molecule Förster resonance energy transfer (smFRET) experiments, we studied how frameshift-inducing stem-loops from E. coli dnaX mRNA and the gag-pol t...

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Literature Corpus work: 1ab1444e-64a2-540b-916e-d00837323dce
DOI: 10.1101/2020.02.05.936120

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