Article

Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across Species

2025-05-05

Abstract excerpt

Nociceptin orphanin F/Q has been implicated in stress-related depressive phenotypes. Specifically, exposure to chronic stressors upregulates nociceptin receptors (NOPR), whereas NOPR antagonism has anti-depressant/anti-anhedonic effects. The mechanisms underlying these effects remain, however, unclear. Here, we investigated the role of NOPR in depressive phenotypes alongside potentially prohedonic effects of NOPR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b01ce6d-93cb-5239-aa34-127bc4e7db13
DOI: 10.1101/2025.05.05.652258

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across SpeciesDOI 10.1101/2025.05.05.652258Read

Sex-Dependent Cross-Resilience to Social Defeat and Learned Helplessness: The Role of BDNF-ERK Signaling and NorepinephrineSemantic proximity Read

Early life stress in male mice blunts responsiveness in a translationally-relevant reward taskSemantic proximity Read

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.Semantic proximity Read

<i>Npbwr1</i> signaling mediates fast antidepressant actionSemantic proximity Read

Npbwr1 signaling mediates fast antidepressant actionSemantic proximity Read

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliencySemantic proximity Read

The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area-Nucleus Accumbens Pathway.Semantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male ratsSemantic proximity Read

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivitySemantic proximity Read

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity Read

PV interneuron alterations in stress-related mood disorders: a systematic reviewSemantic proximity Read