Article

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stress

2026-08-27

Abstract excerpt

Whereas brain systems mediating acute stress are essential for survival, chronic early-life stress (ELA) may lead to poor ability to experience pleasure (anhedonia), a core feature of depression. For decades, the stress neuropeptide corticotropin-releasing hormone (CRH) has been a target for treating depression. However the failure of several clinical trials blocking CRH receptor1 (CRHR1) has left the therapeutic...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 2fb68519-c999-5833-8fca-a3816be69aa1
DOI: 10.64898/2026.08.26.747402

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stressDOI 10.64898/2026.08.26.747402Read

Peptide signaling in the paraventricular thalamus contributes to disrupted adult reward behaviors after early-life adversitySemantic proximity Read

Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice.Semantic proximity Read

Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingSemantic proximity Read

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.Semantic proximity Read

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivitySemantic proximity Read

Early life stress in male mice blunts responsiveness in a translationally-relevant reward taskSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

CRH, stress, and major depression: a psychobiological interplay.Semantic proximity Read

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice.Semantic proximity Read

Spatiotemporal remodeling in the habenula marks the onset of depressionSemantic proximity Read

The neurobiology of depression: inroads to treatment and new drug discovery.Semantic proximity Read

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity Read