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Article

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.

Neuron - 4 Dec 2019

Cerniauskas Ignas, Winterer Jochen, de Jong Johannes W, Lukacsovich David, Yang Hongbin, Khan Fawwad, Peck James R, Obayashi Sophie K, Lilascharoen Varoth, Lim Byung Kook, Földy Csaba, Lammel Stephan

Abstract excerpt

Chronic stress (CS) is a major risk factor for the development of depression. Here, we demonstrate that CS-induced hyperactivity in ventral tegmental area (VTA)-projecting lateral habenula (LHb) neurons is associated with increased passive coping (PC), but not anxiety or anhedonia. LHb→VTA neurons in mice with increased PC show increased burst and tonic firing as well as synaptic adaptations in excitatory inputs...

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Identifiers

PMID: 31672263
DOI: 10.1016/j.neuron.2019.09.005
PMCID: PMC6895430

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