Article

Npbwr1 signaling mediates fast antidepressant action

2024-06-21

Abstract excerpt

<title>Abstract</title> <p>Chronic stress is a major risk factor for depression, a leading cause of disability and suicide. Because current antidepressants work slowly, have common side effects, and are only effective in a minority of patients, there is an unmet need to identify the underlying molecular mechanisms. Here, we reveal the receptor for neuropeptides B and W, Npbwr1, as a key regulator of depressive-li...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ac0bd48-2d22-572f-8ed3-b08f19c61be5
DOI: 10.21203/rs.3.rs-4149042/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Npbwr1 signaling mediates fast antidepressant actionDOI 10.21203/rs.3.rs-4149042/v1Read

<i>Npbwr1</i> signaling mediates fast antidepressant actionSemantic proximity Read

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenulaSemantic proximity Read

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets.Semantic proximity Read

Spatiotemporal remodeling in the habenula marks the onset of depressionSemantic proximity Read

Recent advances in depression research: from stress to molecular biology and brain imaging.Semantic proximity Read

Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes.Semantic proximity Read

Are we getting closer to valid translational models for major depression?Semantic proximity Read

Depression-like phenotype following chronic CB1 receptor antagonism.Semantic proximity Read

HBK-15 bypasses BDNF via ERK1/2-biased 5-HT1A receptor signaling to deliver a rapid antidepressant-like effectSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

Integrative Mouse and Human mRNA Studies Using WGCNA Nominates Novel Candidate Genes Involved in the Pathogenesis of Major Depressive DisorderSemantic proximity Read

Neurobiology of depression and novel antidepressant drug targets.Semantic proximity Read