Article

Sex-Dependent Cross-Resilience to Social Defeat and Learned Helplessness: The Role of BDNF-ERK Signaling and Norepinephrine

2025-10-28

Abstract excerpt

Major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are two of the most prevalent and disabling psychiatric conditions, both closely tied to stress exposure. While they have distinct diagnostic criteria, MDD and PTSD share considerable comorbidity, overlapping behavioral symptoms, and common neurobiological pathways. However, not all individuals exposed to chronic or traumatic stress develop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ead966d4-d88a-5474-87e9-44138614f58b
DOI: 10.1101/2025.10.27.684864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sex-Dependent Cross-Resilience to Social Defeat and Learned Helplessness: The Role of BDNF-ERK Signaling and NorepinephrineDOI 10.1101/2025.10.27.684864Read

Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice.Semantic proximity Read

Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across SpeciesSemantic proximity Read

Neural mechanisms of stress resilience and vulnerability.Semantic proximity Read

The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area-Nucleus Accumbens Pathway.Semantic proximity Read

A Clinically Aligned Murine Model of Electroconvulsive Stimulation Reverses Social Aversion and Displays Fear Memory Impairment After Chronic Social Defeat StressSemantic proximity Read

Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depressionSemantic proximity Read

mRNA and microRNA Profiles in the Amygdala Are Relevant to Susceptibility and Resilience to Psychological Stress Induced in Mice.Semantic proximity Read

Transcriptomic analyses of humans and mice provide insights into depression.Semantic proximity Read

Network Adaptability Governs Resilience and Susceptibility to Social DefeatSemantic proximity Read

Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingSemantic proximity Read

High susceptibility to chronic social stress is associated with a depression-like phenotype.Semantic proximity Read

Nucleus accumbens neuron subtype translatome signatures in socially stressed femalesSemantic proximity Read