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Article

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 1999

Köster A, Montkowski A, Schulz S, Stübe E M, Knaudt K, Jenck F, Moreau J L, Nothacker H P, Civelli O, Reinscheid R K

Abstract excerpt

The neuropeptide orphanin FQ (also known as nociceptin; OFQ/N) has been implicated in modulating stress-related behavior. OFQ/N was demonstrated to reverse stress-induced analgesia and possess anxiolytic-like activity after central administration. To further study physiological functions of OFQ/N...

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Identifiers

PMID: 10468628
DOI: 10.1073/pnas.96.18.10444
PMCID: PMC17908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10468628-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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