Article

<i>Npbwr1</i> signaling mediates fast antidepressant action

2024-02-04

Abstract excerpt

Chronic stress is a major risk factor for depression, a leading cause of disability and suicide. Because current antidepressants work slowly, have common side effects, and are only effective in a minority of patients, there is an unmet need to identify the underlying molecular mechanisms. Here, we reveal the receptor for neuropeptides B and W, Npbwr1 , as a key regulator of depressive-like symptoms. Npbwr1 is in...

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Literature Corpus work: cade3afa-848e-59d4-b102-841676464175
DOI: 10.1101/2024.02.02.578166

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