Article

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety, suicide, and other psychiatric disorders, particularly after facing additional stressful events later in life. Human and animal studies demonstrate that ELS sensitizes individuals to subsequent stress. However, the neurobiological basis of such stress sensitization remains largely unexplored. We hypoth...

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Literature Corpus work: 1c8f081b-a4e7-5595-8c29-9ea662d91f55
DOI: 10.1101/2022.12.21.521303

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