Article
Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.
Neuron - 6 Mar 2024
Li Haiyan, Kawatake-Kuno Ayako, Inaba Hiromichi, Miyake Yuka, Itoh Yukihiro, Ueki Takatoshi, Oishi Naoya, Murai Toshiya, Suzuki Takayoshi, Uchida Shusaku
Abstract excerpt
Chronic stress is a major risk factor for psychiatric disorders, including depression. Although depression is a highly heterogeneous syndrome, it remains unclear how chronic stress drives individual differences in behavioral responses. In this study, we developed a subtyping-based approach wherein stressed male mice were divided into four subtypes based on their behavioral patterns of social interaction deficits...
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