Article

Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats

2024-06-01

Abstract excerpt

Preclinical and human studies indicate psilocybin may reduce perseverant maladaptive behaviors, including nicotine and alcohol seeking. Such studies in the opioid field are lacking, though opioids are involved in more >50% of overdose deaths. Psilocybin is an agonist at the serotonin 2A receptor (5-HT 2A R), a well-documented target for modulation of drug seeking, and evidence suggests 5-HT 2A R agonists may dam...

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Literature Corpus work: 9cbccf6d-b21e-5238-be34-cb10455f95e0
DOI: 10.1101/2024.05.28.596205

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