Article
The Resilient Phenotype Induced by Prophylactic Ketamine Exposure During Adolescence Is Mediated by the Ventral Tegmental Area-Nucleus Accumbens Pathway.
Biological psychiatry - 1 Oct 2021
Parise Eric M, Parise Lyonna F, Sial Omar K, Cardona-Acosta Astrid M, Gyles Trevonn M, Juarez Barbara, Chaudhury Dipesh, Han Ming-Hu, Nestler Eric J, Bolaños-Guzmán Carlos A
Abstract excerpt
BACKGROUND: Major depressive disorder is prevalent in children and adolescents and is associated with a high degree of morbidity throughout life, with potentially devastating personal consequences and public health impact. The efficacy of ketamine (KET) as an antidepressant has been demonstrated in adolescent rodents; however, the neurobiological mechanisms underlying these effects are unknown. Recent evidence...
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