Article
<i>dN/dS</i> dynamics quantify tumour immunogenicity and predict response to immunotherapy
2020-07-22
Abstract excerpt
Immunoediting is a major force during cancer evolution that selects for clones with low immunogenicity (adaptation), or clones with mechanisms of immune evasion (escape). However, quantifying immunogenicity in the cancer genome and how the tumour-immune coevolutionary dynamics impact patient outcomes remain unexplored. Here we show that the ratio of nonsynonymous to synonymous mutations (dN/dS) in the immunopeptid...
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Identifiers and source
- Literature Corpus work
- 1abb9aa2-9040-5084-892f-35104efcd044
- DOI
- 10.1101/2020.07.21.215038