Article

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

2023-08-02

Abstract excerpt

<title>Abstract</title> <p>Cancer progression is an evolutionary process undergoing stringent immune selection. However, recent studies have revealed that certain tumors undergo neutral evolution following the malignant transformation. Here, we propose negative frequency-dependent selection (or NFDS), where the immune response against cancer cells depends on the clonality of neoantigens, can lead to an immunogeni...

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Literature Corpus work: b8a3664b-82d5-514a-88b6-3f6cf3b56007
DOI: 10.21203/rs.3.rs-3215481/v1

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