Article

Pan-cancer evolution signatures link clonal expansion to dynamic changes in the tumour immune microenvironment

2023-10-13

Abstract excerpt

<h4>ABSTRACT</h4> Cancer is an evolutionary process characterised by profound intra-tumour heterogeneity. Intra-tumour heterogeneity can be quantified using in silico estimates of cancer cell fractions of tumour-specific somatic mutations. Here we demonstrate a data-driven approach that uses cancer cell fraction distributions to identify 4 robust pan-cancer evolutionary signatures from an analysis of 4,146 indivi...

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Literature Corpus work: 77375dd3-1d0c-5c01-a4ad-a02830072f93
DOI: 10.1101/2023.10.12.560630

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