Article

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

2023-08-03

Abstract excerpt

Cancer is an evolutionary process undergoing stringent immune selection. However, recent studies have revealed that certain tumors undergo neutral evolution following the malignant transformation. Here, we propose negative frequency-dependent selection (or NFDS), where the immune response against cancer cells depends on the clonality of neoantigens, can lead to an immunogenic landscape that is similar to neutral e...

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Literature Corpus work: 2af94cb6-1f22-5f79-b262-ba9f00361825
DOI: 10.1101/2023.08.01.551090

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