Article

Quantifying Immune-Based Counterselection of Somatic Mutations

2017-11-14

Abstract excerpt

<h4>ABSTRACT</h4> It is now well established that somatic mutations in protein-coding regions can generate ‘neoantigens’, and that these can be recognized by the immune system and contribute to clearance of developing cancers. However, there is currently no model that can quantitatively predict the neoantigenic effect of any given somatic mutation. Here, we examined signatures of immune selection pressure on the...

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Literature Corpus work: a3d3d9df-85bb-51a7-a32b-cc545757e741
DOI: 10.1101/219576

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