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Article

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors.

Nature genetics - 1 Mar 2023

Zapata Luis, Caravagna Giulio, Williams Marc J, Lakatos Eszter, AbdulJabbar Khalid, Werner Benjamin, Chowell Diego, James Chela, Gourmet Lucie, Milite Salvatore, Acar Ahmet, Riaz Nadeem, Chan Timothy A, Graham Trevor A, Sottoriva Andrea

Abstract excerpt

In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356 immune-checkpoint-treated metastases using immune dN/dS, the ratio of nonsynonymous to synonymous mutations in the immunopeptidome, to measure immune selection in cohorts and individuals. We classified tumors as immune edited when antigenic mutations were removed by negative selection and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36894710
DOI: 10.1038/s41588-023-01313-1
PMCID: PMC10011129

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