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Article

Genetic immune escape landscape in primary and metastatic cancer.

Nature genetics - 1 May 2023

Martínez-Jiménez Francisco, Priestley Peter, Shale Charles, Baber Jonathan, Rozemuller Erik, Cuppen Edwin

Abstract excerpt

Studies have characterized the immune escape landscape across primary tumors. However, whether late-stage metastatic tumors present differences in genetic immune escape (GIE) prevalence and dynamics remains unclear. We performed a pan-cancer characterization of GIE prevalence across six immune escape pathways in 6,319 uniformly processed tumor samples. To address the complexity of the HLA-I locus in the germline...

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Identifiers

PMID: 37165135
DOI: 10.1038/s41588-023-01367-1
PMCID: PMC10181939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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