Immune evasion impacts the selective landscape of driver genes during tumorigenesis

Abstract excerpt

Carcinogenesis is an evolutionary process fueled by the interplay of somatic mutations and the local microenvironment. In recent years, hundreds of cancer related genes have been discovered using cancer cohorts. However, these cohorts are heterogenous mixtures of different molecular phenotypes, which hampers the identification of driver genes associated to a specific cancer hallmark or microenvironment. Here, we c...

Topics

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• Evolution, Molecular
• Immune Cell Function and Interaction
• Immune Evasion
• Mutation
• Neoplasms
• Neoplasms, Second Primary
• Tumor Escape
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

3d6c3d6e-e4b8-5654-b87a-3b072523628d

DOI

10.1101/2022.06.20.496910