Article

Evolution of the nonsense mediated decay (NMD) pathway is associated with decreased cytolytic immune infiltration

2019-02-04

Abstract excerpt

<h4>Background</h4> The somatic co-evolution of tumors and the cellular immune responses that combat them drives the diversity of immune-tumor interactions. This includes tumor mutations that generate neo-antigenic epitopes that elicit cytotoxic T-cell activity and subsequent pressure to select for genetic loss of antigen presentation. Most studies have focused on how tumor missense mutations can drive tumor immu...

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Literature Corpus work: e9692c2b-3a01-52e4-9eeb-fa9cccf01811
DOI: 10.1101/535773

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