Article

SATB2 organizes the 3D genome architecture of cognition in cortical neurons

2022-12-29

Abstract excerpt

<h4>Summary</h4> SATB2 is genetically associated with human intelligence. Since SATB2 protein structure predicts a function in DNA looping, we analyzed the impact of SATB2 on 3D genome architecture and chromatin accessibility in cortical neurons. Our data reveal strong effects of SATB2 on chromatin looping between enhancers and promoters of neuronal activity-regulated genes, which closely correlate with gene expr...

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Literature Corpus work: 1a90df1d-c50a-539b-adcb-38c7b157477a
DOI: 10.1101/2022.12.27.522010

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