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Article

Chromosome conformation elucidates regulatory relationships in developing human brain.

Nature - 27 Oct 2016

Won Hyejung, de la Torre-Ubieta Luis, Stein Jason L, Parikshak Neelroop N, Huang Jerry, Opland Carli K, Gandal Michael J, Sutton Gavin J, Hormozdiari Farhad, Lu Daning, Lee Changhoon, Eskin Eleazar, Voineagu Irina, Ernst Jason, Geschwind Daniel H

Abstract excerpt

Three-dimensional physical interactions within chromosomes dynamically regulate gene expression in a tissue-specific manner. However, the 3D organization of chromosomes during human brain development and its role in regulating gene networks dysregulated in neurodevelopmental disorders, such as autism or schizophrenia, are unknown. Here we generate high-resolution 3D maps of chromatin contacts during human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27760116
DOI: 10.1038/nature19847
PMCID: PMC5358922

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FOXG1

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