Article

Cognitive function depends upon <i>Satb2</i> gene dosage in cortical projection neurons

2026-06-16

Abstract excerpt

SATB2-associated syndrome (SAS) is a severe neurodevelopmental disorder caused by de novo heterozygous SATB2 mutations, yet how haploinsufficiency disrupts brain development remains poorly understood. While homozygous Satb2 loss causes profound embryonic cell-fate defects, we demonstrate using a heterozygous mouse model that SAS phenotypes emerge primarily during postnatal circuit maturation. Integrating chroma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c395406b-a0cb-58ce-87bd-7314df7027d3
DOI: 10.64898/2026.06.13.731750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cognitive function depends upon <i>Satb2</i> gene dosage in cortical projection neuronsDOI 10.64898/2026.06.13.731750Read

Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.Semantic proximity Read

SATB2 organizes the 3D genome architecture of cognition in cortical neuronsSemantic proximity Read

Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.Semantic proximity Read

Polycomb Repressive Complex 2 is critical for mouse cortical glutamatergic neuron developmentSemantic proximity Read

Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophrenia.Semantic proximity Read

Leveraging mouse chromatin data for heritability enrichment informs common disease architecture and reveals cortical layer contributions to schizophreniaSemantic proximity Read

ASXL3 controls cortical neuron fate specification through extrinsic self-renewal pathwaysSemantic proximity Read

<i>Arid1b</i> haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypesSemantic proximity Read

A network of genetic repression and derepression specifies projection fates in the developing neocortex.Semantic proximity Read

The determination of projection neuron identity in the developing cerebral cortex.Semantic proximity Read

SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes.Semantic proximity Read

GATAD2B loss-of-function mutations cause a recognisable syndrome with intellectual disability and are associated with learning deficits and synaptic undergrowth in Drosophila.Semantic proximity Read