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Article

SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes.

The EMBO journal - 1 Feb 2021

Feurle Patrick, Abentung Andreas, Cera Isabella, Wahl Nico, Ablinger Cornelia, Bucher Michael, Stefan Eduard, Sprenger Simon, Teis David, Fischer Andre, Laighneach Aodán, Whitton Laura, Morris Derek W, Apostolova Galina, Dechant Georg

Abstract excerpt

SATB2 is a schizophrenia risk gene and is genetically associated with human intelligence. How it affects cognition at molecular level is currently unknown. Here, we show that interactions between SATB2, a chromosomal scaffolding protein, and the inner nuclear membrane protein LEMD2 orchestrate the response of pyramidal neurons to neuronal activation. Exposure to novel environment in vivo causes changes in nuclear...

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Identifiers

PMID: 33319920
DOI: 10.15252/embj.2019103701
PMCID: PMC7849313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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