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The 3D genome of pediatric B-cell precursor acute lymphoblastic leukemia

2025-07-25

Abstract excerpt

Whereas the molecular pathogenesis of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) has been studied extensively, its 3D chromatin landscape – of vast importance for gene regulation – remains poorly explored. Here, we applied Micro-C, a high-resolution variant of Hi-C, to 35 primary pediatric BCP ALL cases, spanning all major genetic subtypes. We present a complete view of the chromatin interac...

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Identifiers and source

Literature Corpus work
225e2440-acf4-5ec5-9023-1a8dc7352811
DOI
10.1101/2025.07.22.666073
Open publication

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The 3D genome of pediatric B-cell precursor acute lymphoblastic leukemiaDOI 10.1101/2025.07.22.666073
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