Article

Polygenic risk scores for incident dementia in the Multi-Ethnic Study of Atherosclerosis

2025-03-06

Abstract excerpt

Over 75 Alzheimer’s disease (AD) and dementia-associated variants have been identified through genome-wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dementia in diverse and admixed populations remains unclear. We compared how PRS approaches differing in p -value thresholds, variant weights, and source ancestry perform in predicting dementia in 6,338 African American...

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Literature Corpus work: 19f32ab5-51e2-5580-9a49-ebdf6d89b760
DOI: 10.1101/2025.03.05.25323412

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