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Validation of newly derived polygenic risk scores for dementia in a prospective study of older individuals

12 May 2023

Abstract excerpt

INTRODUCTION: Recent genome-wide association studies identified new dementia-associated variants. We assessed the performance of updated polygenic risk scores (PRSs) using these variants in an independent cohort. METHODS: We used Cox models and area under the curve (AUC) to validate new PRSs (PRS-83SNP, PRS-SBayesR, and PRS-CS) compared with an older PRS-23SNP in 12,031 initially-healthy participants ≥70 years of...

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PMID: 37177856
DOI: 10.1002/alz.13113

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