Article
A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
Alzheimer's research & therapy - 30 Aug 2023
Sofer Tamar, Kurniansyah Nuzulul, Granot-Hershkovitz Einat, Goodman Matthew O, Tarraf Wassim, Broce Iris, Lipton Richard B, Daviglus Martha, Lamar Melissa, Wassertheil-Smoller Sylvia, Cai Jianwen, DeCarli Charles S, Gonzalez Hector M, Fornage Myriam
Abstract excerpt
INTRODUCTION: Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome. METHODS: We used summary statistics from five GWASs of AD to construct PRSs in 4,189 diverse Hispanics/Latinos (mean age 63 years) from the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA). We assessed the PRS associations with MCI in the combined set of people and in diverse subgroups, and when...
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