Article
A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.
Nature genetics - 1 Sept 2026
Kurniansyah Nuzulul, Tasaki Shinya, Rehman Habbibur, Zhu Congcong, Farrell John, Sherva Richard, Hauger Richard, Merritt Victoria C, Panizzon Matthew, Zhang Rui, Gaziano J Michael, Gim Jungsoo, Lee Kunho, Lee Dong Yong, Nho Kwansik, Vialle Ricardo A, Mukherjee Shubhabrata, Trittschuh Emily H, Lee Annie J, Brickman Adam M, Cruchaga Carlos, Risacher Shannon, Greve Douglas N, Crane Paul, Martin Eden, Bush William S, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Logue Mark, Bennett David A, Barnes Lisa L, Saykin Andrew, Hohman Timothy, Wang Li-San, Schellenberg Gerard D, Ang Ting Fang Alvin, Au Rhoda, Mez Jesse, Lunetta Kathryn L, Zhang Xiaoling, Farrer Lindsay A
Abstract excerpt
Previously derived polygenic risk scores (PRSs) for Alzheimer's disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ancestry, African American, Caribbean Hispanic and East Asian cohorts. PRS performance was evaluated in a large independent multiancestry dataset and validated...
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