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Article

Risk score roulette: A cautionary tale of polygenic risk score reliability.

Journal of Alzheimer's disease : JAD - 1 Nov 2025

Xue Diane, Blue Elizabeth E, Wood Alexis C, Rotter Jerome I, Fohner Alison E

Abstract excerpt

Genetic risk prediction for Alzheimer's disease (AD) has high potential impact, yet few studies have assessed the reliability of various polygenic risk score (PRS) methods at the individual level. Here, we evaluated the reliability of AD PRS estimates among 6338 participants from the Multi-Ethnic Study of Atherosclerosis. We compared four PRS models that have been previously associated with dementia risk. Despite...

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Identifiers

PMID: 40924585
DOI: 10.1177/13872877251375098
PMCID: PMC12541115

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