Article

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Genome-wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer’s disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low. Here, we evaluated the predictive accuracy of single-, multi-, and cross-ancestry AD-PRS models across multi-ancestral populatio...

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Literature Corpus work: 4752346a-3fbf-541b-bd0a-fbf94f6b74c6
DOI: 10.1101/2025.10.03.25337285

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