Article

Identifying Individuals at High Risk for Alzheimer’s Disease Among Hispanics Using Single and Multi-Ancestry Polygenic Risk Scores

2024-10-22

Abstract excerpt

<h4>Introduction</h4> Polygenic risk score (PRS) is effective in predicting AD risk among Europeans but remains understudied in Hispanics. Diverse genome-wide association studies (GWAS) data across multiple ancestries may improve PRS predictions. We evaluated PRS performance to predict AD disease risk using novel methods in the largest available African, European, and Hispanic GWAS for AD. <h4>Methods</h4> Predict...

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Literature Corpus work: fee4c7f9-4e0d-5560-865f-65ee2badb540
DOI: 10.1101/2024.10.21.24315877

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