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Article

Polygenic Risk Scores for Incident Dementia in the Multi-Ethnic Study of Atherosclerosis.

Genetic epidemiology - 1 Jul 2026

Xue Diane, Blue Elizabeth E, Sofer Tamar, Hughes Timothy M, Rotter Jerome I, Post Wendy S, Fohner Alison E

Abstract excerpt

Over 75 Alzheimer's disease (AD) and dementia-associated variants have been identified through genome-wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dementia in diverse and admixed populations remains unclear. We compared how PRS approaches differing in p-value thresholds, variant weights, and source ancestry perform in predicting dementia in 6338 African American,...

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PMID: 42334086
DOI: 10.1002/gepi.70046
PMCID: PMC13288446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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