Article

The transcription factor STAT5 binds to distinct super-enhancer sites and controls <i>Lrrc32</i> expression in a prominent autoimmune and allergic disease risk locus

2020-06-15

Abstract excerpt

<h4>Summary</h4> Genetic variants associated with diseases are enriched in genomic sequences linked to regulatory regions, such as enhancers, super-enhancers and possibly repressors, that control nearby and distant genes. A known allergic and autoimmune risk locus at chromosome 11q13.5 1,2 is associated with the LRRC32 gene, which encodes GARP, a protein critical for TGF-β delivery 3 . This region coincides wi...

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Literature Corpus work: 19d06ee9-92cf-50f7-bba9-c163dc0ce646
DOI: 10.1101/2020.06.13.150177

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