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Article

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.

Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2017

Li Peng, Mitra Suman, Spolski Rosanne, Oh Jangsuk, Liao Wei, Tang Zhonghui, Mo Fei, Li Xingwang, West Erin E, Gromer Daniel, Lin Jian-Xin, Liu Chengyu, Ruan Yijun, Leonard Warren J

Abstract excerpt

Cytokines critically control immune responses, but how regulatory programs are altered to allow T cells to differentially respond to distinct cytokine stimuli remains poorly understood. Here, we have globally analyzed enhancer elements bound by IL-2-activated STAT5 and IL-21-activated STAT3 in T cells and identified Il2ra as the top-ranked gene regulated by an IL-2-activated STAT5-bound superenhancer and one of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29078395
DOI: 10.1073/pnas.1714019114
PMCID: PMC5699083

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.PMID 29078395Read ↗

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