Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mammary-Enriched Transcription Factors Synergize to Activate the Wap Super-Enhancer for Mammary Gland Development.

International journal of molecular sciences - 2 Oct 2022

Kim Uijin, Kim Suyeon, Kim Nahyun, Shin Ha Youn

Abstract excerpt

Super-enhancers are large clusters of enhancers critical for cell-type-specific development. In a previous study, 440 mammary-specific super-enhancers, highly enriched for an active enhancer mark H3K27ac; a mediator MED1; and the mammary-enriched transcription factors ELF5, NFIB, STAT5A, and GR, were identified in the genome of the mammary epithelium of lactating mice. However, the triggering mechanism for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer Elements, Genetic
Share to Gene Editing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lactation

Share to Mutation

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 36232979
DOI: 10.3390/ijms231911680
PMCID: PMC9569684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mammary-Enriched Transcription Factors Synergize to Activate the Wap Super-Enhancer for Mammary Gland Development.PMID 36232979Read ↗

Hierarchy within the mammary STAT5-driven Wap super-enhancer.Semantic proximity Read ↗

Integrative analysis reveals genomic and epigenomic signatures of super-enhancers and its constituentsSemantic proximity Read ↗

Super-enhancers in the control of cell identity and disease.Semantic proximity Read ↗

What are super-enhancers?Semantic proximity Read ↗

dbSUPER: a database of super-enhancers in mouse and human genomeSemantic proximity Read ↗

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.Semantic proximity Read ↗

Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1Semantic proximity Read ↗

Super-enhancers are transcriptionally more active and cell-type-specific than stretch enhancersSemantic proximity Read ↗

A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loopsSemantic proximity Read ↗

Essential genes are dominantly activated by single transcription factorsSemantic proximity Read ↗

Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms.Semantic proximity Read ↗

A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.