Article
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nature - 1 Jul 2020
Nasrallah Rabab, Imianowski Charlotte J, Bossini-Castillo Lara, Grant Francis M, Dogan Mikail, Placek Lindsey, Kozhaya Lina, Kuo Paula, Sadiyah Firas, Whiteside Sarah K, Mumbach Maxwell R, Glinos Dafni, Vardaka Panagiota, Whyte Carly E, Lozano Teresa, Fujita Toshitsugu, Fujii Hodaka, Liston Adrian, Andrews Simon, Cozzani Adeline, Yang Jie, Mitra Suman, Lugli Enrico, Chang Howard Y, Unutmaz Derya, Trynka Gosia, Roychoudhuri Rahul
Abstract excerpt
Genetic variations underlying susceptibility to complex autoimmune and allergic diseases are concentrated within noncoding regulatory elements termed enhancers1. The functions of a large majority of disease-associated enhancers are unknown, in part owing to their distance from the genes they regulate, a lack of understanding of the cell types in which they operate, and our inability to recapitulate the biology of...
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