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Article

Hierarchy within the mammary STAT5-driven Wap super-enhancer.

Nature genetics - 1 Aug 2016

Shin Ha Youn, Willi Michaela, HyunYoo Kyung, Zeng Xianke, Wang Chaochen, Metser Gil, Hennighausen Lothar

Abstract excerpt

Super-enhancers comprise dense transcription factor platforms highly enriched for active chromatin marks. A paucity of functional data led us to investigate the role of super-enhancers in the mammary gland, an organ characterized by exceptional gene regulatory dynamics during pregnancy. ChIP-seq analysis for the master regulator STAT5A, the glucocorticoid receptor, H3K27ac and MED1 identified 440 mammary-specific...

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Topics

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Share to Enhancer Elements, Genetic
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mice, Knockout

Share to Milk Proteins

Share to Pregnancy

Share to STAT5 Transcription Factor

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 27376239
DOI: 10.1038/ng.3606
PMCID: PMC4963296

Genes

ELF5
MED1
NFIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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