Article

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammation

2021-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Intestine homeostasis is maintained by the delicate balance of Th17 effector cells and Treg cells. Dysregulation of these cell populations contributes to inflammation, tissue damage, and chronic conditions. RORγt is essential for the differentiation of Th17 and a subset of Treg (RORγt + Treg) cells involved in intestinal inflammation. RORγt belongs to the nuclear receptor family of transcriptio...

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Literature Corpus work: e064346f-18ba-5ce4-84ed-1835ec9e96b2
DOI: 10.1101/2021.05.14.444071

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