Article

T cell subset-selective <i>IL2RA</i> enhancers shape autoimmune diabetes risk

2020-07-22

Abstract excerpt

The majority of genetic variants associated with complex human autoimmune diseases reside in enhancers 1–3 , non-coding regulatory elements that control gene expression. In contrast with variants that directly alter protein-coding sequences, enhancer variants are predicted to tune gene expression modestly and function in specific cellular contexts 4 , suggesting that small alterations in the functions of key imm...

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Identifiers and source

Literature Corpus work: 7ad31768-7510-59e2-b032-b873f9ee7a2d
DOI: 10.1101/2020.07.22.216564

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