Article
Super-enhancers delineate disease-associated regulatory nodes in T cells.
Nature - 23 Apr 2015
Vahedi Golnaz, Kanno Yuka, Furumoto Yasuko, Jiang Kan, Parker Stephen C J, Erdos Michael R, Davis Sean R, Roychoudhuri Rahul, Restifo Nicholas P, Gadina Massimo, Tang Zhonghui, Ruan Yijun, Collins Francis S, Sartorelli Vittorio, O'Shea John J
Abstract excerpt
Enhancers regulate spatiotemporal gene expression and impart cell-specific transcriptional outputs that drive cell identity. Super-enhancers (SEs), also known as stretch-enhancers, are a subset of enhancers especially important for genes associated with cell identity and genetic risk of disease. CD4(+) T cells are critical for host defence and autoimmunity. Here we analysed maps of mouse T-cell SEs as a...
Topics
- Animals
- Arthritis, Rheumatoid
- Basic-Leucine Zipper Transcription Factors
- Cell Differentiation
- Cell Lineage
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Janus Kinase 3