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Article

Critical roles of super-enhancers in the pathogenesis of autoimmune diseases

3 Aug 2020

Abstract excerpt

The super-enhancer (SE) is a cluster of enhancers involved in cell differentiation via enhanced gene expression that determines cell identity. Meanwhile, genome-wide association studies (GWASs) have reported the presence of gene clusters containing single nucleotide polymorphisms (SNPs) susceptible to various diseases. According to cell types, these disease-susceptible SNPs are frequently detected in activated SE...

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PMID: 32922569
DOI: 10.1186/s41232-020-00124-9

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