Article

Cross-species permissivity: structure of a goat adeno-associated virus and its complex with the human receptor, AAVR

2022-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated virus (AAV) is a small ssDNA satellite virus of high interest (in recombinant form) as a safe and effective gene therapy vector. AAV’s human cell entry receptor (AAVR) contains Polycystic Kidney Disease (PKD) domains bound by AAV. Seeking understanding of the spectrum of interactions, goat AAVGo.1 is investigated, because its host is the species most distant from human with reci...

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Literature Corpus work: 19c8a141-f853-52f2-bd39-cf814bb7b1c5
DOI: 10.1101/2022.01.14.476406

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